Boresha B-Skinny™ Coffee represents revolutionary advances in food-science, and was named “Breakthrough Product of the Year” by Success magazine.

PATENTED INGREDIENTS

Boresha B-Skinny™ Coffee contains a unique Patented, fat-burning blend designed to provide energy enhancement in humans:

•	Patented Buffered Caffeine
•	Certified Balanced-Energy Low Glycemic Fruit Base
•	Niacin-Bound Chromium

PRODUCTION OF HIGHER ENERGY LEVELS: THE MECHANISM

Boresha B-Skinny™ Coffee delivers high energy levels and alertness in humans, not by speeding you up, but by keeping you from slowing down.

Each time brain cells fire, they product a squirt of a chemical that serves as an off-switch that keeps neural activity in check.

Boresha B-Skinny™ Coffee biochemically blocks the chemical, and jams the switch, so it can’t be turned down. This energy-effect can last from 2-4 hours.

Additionally, the time-released fruit glycoside system unique to the formula remains in the intestinal tract for a long period, providing increased energy over a 2-to-4 hour duration.

PHYSIOLOGICAL EFFECTS

Boresha B-Skinny™ Coffee is effective at increasing energy, enacting thermogenesis via DIT, and adipose-tissue-fat-burning (ATFB), via the following mechanisms:

•	Stimulates under-functioning adrenal glands by increasing the output of epinephrine and norepinephrine from the adrenal glands.
•	Stimulates the release of catecholamines from the adrenal medulla and releases catecholamines due to a central action by and affecting C-AMP.
•	Donates methyl groups in anabolic processes (Rivici Index).
•	Increases energy expenditure dose dependently. Stepwise regression analysis with the thermogenic response as the dependent variable yields the following equation: (proprietary) as provided to our FDA-Regulatory attorneys for Skinny Science® Coffee Thermogenics; validation of efficacy.
•	Turns on Brown-Fat-Thermogenesis in humans.
•	Removes adenos and phosphodiesterase blocks to thermogenesis in humans.
•	Triggers noradrenalin to active thermogenesis in isolated brown adipocytes by stimulating lipolysis.
•	Inclusion of Low Glycemic, thermogenic carbohydrates and PP glycosides that down-regulate Lipoprotein Lipase (LPL).
•	Inclusion of Buffered Caffeine (full U.S. Patent) that does not exhibit the adipose-tissue fat-storing properties of regular caffeine.

Boresha B-Skinny™ Coffee BODY OF RESEARCH Human In Vivo Clinical Research & Trials

•	Anti-Carbohydrate properties, clinical studies, and metabolic effects in humans.
•	Low Glycemic Responses to specific Anti-Carbohydrate Fruit Sweeteners; Human In Vivo Clinical Trials.
•	Blood glucose effect of sugars, sweeteners and carbohydrates, circulating adiponectin (ACRP30), metabolic syndrome and sweeteners, genetic mutations in the leptin gene, adipocyte glucose metabolism, decreased glucose-induced thermogenesis (DGIT), circulating C peptide concentrations and insulin resistance, substrate utilization of carbohydrates and sweeteners.
•	The Insulin-Leptin-Ghrelin relationship in energy metabolism, improvement of glucose tolerance in type 2 diabetics in response to acute catalytic low-dose fruit glycosides, muscle glycogen and carbohydrates, Liporotein Lipase (LPL) and sugars.
•	Fruit Glycosides that do not trigger adipose tissue fat-storage, diabetes, or insulin resistance in humans, pathogenesis of obesity and Diet-Induced-Thermogenic (DIT) agents in humans.
•	Thermogenic and fat-storing response of carbohydrates, sugars and sweeteners, stimulation of fat-storing enzymes in humans, White and Brown Adipose Tissue (BAT) and thermogenesis, internal vs DIT thermogenesis, thermogenic capacity of cells and tissues.
•	UCP in mitochondria, Resistin, lipolytic actions in humans, appestat centers of the brain, identification and reduction of fat cell mass in humans, caloric conversion info fat cells, human genetic code related to deposition of adipose tissue body fat, N.E.A.T., fat thermostat in humans, hypothalamus-related fat-storage, cellular level thermogenesis, caffeine and DIT.
•	Methods for buffering caffeine to eliminate fat-storage in fat cells, caffeine thermogenesis, LPL gatekeepers for fat-storage in the fat cell, chromium and thermogenesis, chocolate and Serotonin-response in human female population.
•	Agents that activate Serotonin, high-protein diets and reduced thermogenesis, aging and adipose tissue fat accumulation, adipocyte lineage, regulation of beta-3-adrenoceptor expression in white vs brown fat cells.

PATHOBIOCHEMICAL & CLINICAL ASPECTS of FAT STORAGE

Adipose tissue (body fat) is a highly active endocrine organ secreting a range of hormones. Energy metabolism and its regulation determine the rate of fat-burning in an individual.

Resisten, Leptin, Ghrelin, Adiponectin, and Lipoprotein Lipase (LPL) play major roles in the function and storage of adipose tissue fat in humans. Leptin (a satiety hormone), adiponectin, and resistin are produced by adipose tissue fat cells. LPL directs food into the fat cells, and is triggered by ingesting high glycemic, fattening foods and/or drinks.

As fat cells increase in size and/or number, Resistin increases, causing increased risk of insulin resistance, obesity, and type 2 diabetes (8). Circulating adiponectin (ACRP30) levels decrease as age progresses, which further increases risk of insulin resistance and type 2 diabetes.

As age increases in humans, adiponectin levels lower, triggering increased abdominal fat deposition, disrupted carbohydrate metabolism, and hyperlipidemia. As a result of these combined factors, decreased thermogenesis is evidenced as humans age and as they gain weight.

PATENTED THERMOGENIC FAT-BURNING

The form of thermogenesis in humans activated by Boresha B-Skinny™ Coffee called Diet-Induced-Thermogenesis (DIT) and is well known in the scientific literature.

Boresha B-Skinny™ Coffee produces a DIT thermogenic effect, de novo lipogenesis, as well as carbohydrate oxidation (burning) in a Proprietary Low Glycemic matrix.

BORESHA B-SKINNY™ COFFEE ANTI-GLUCOSE MATRIX


Boresha B-Skinny™ Coffee contains a specially formulated ANTI-GLUCOSE MATRIX that addresses key areas in fat-burning metabolism:

In order to combat Stress-Related-Eating (SRE) and False-Food-Cravings, the human body requires the opposite of Glucose-elevation, which is a Low Glycemic Matrix.

A Low Glycemic Matrix does not stimulate glucose, and conversely helps block False-Food-Cravings. The unique Matrix found in Boresha B-Skinny™ Coffee provides a mechanism for blocking fat-storage and glucose-fat-storage.

The human body, and specifically the brain, requires at least 130 grams of carbohydrates per day for cognitive function and energy. Low energy levels and impaired cognitive function are typical when following a low carb diet.

High glycemic carbohydrates cause glucose and blood sugar swings, fat-storage, and weight gain.

High protein, and low carb diets and foods, exacerbate (worsen) the biochemical stress machine by depriving the body of stress-calming carbohydrates.

Thermogenic drinks and compounds that do not contain a Low Glycemic Matrix cause fat-storage.

STRESS LEADS TO WEIGHT GAIN


Stress, as every woman can attest, causes weight gain.

The link between stress and weight gain has been scientifically proven. At Georgetown University Medical Center, researchers showed that stress conditions cause weight gain, even when caloric intake does not vary.

Stress, experienced as a part of everyday life, triggers the body’s conversion of food energy into glucose as a fight-or-flight hard-wired mechanism. Neuropeptide Y (NPY) is elevated during stress.

NPY attaches to a receptor, a molecular doorway, in fat cells that is called Neuropeptide Y2 receptor, or Y2R. It activates fat cells and some of the cells in blood vessels found in fat tissue.

This cascade of fat-storage mechanisms leads to weight gain as well as depletion of specific B vitamins (particularly B-6), as they are utilized in the Glucose-Producing-Reaction (GPR). As glucose and NPY levels rise, weight gain increases in adipose tissue fat cells.

The human body is hard-wired to gain belly-fat under stress, even mild chronic stress.

STRESS EATING

Stress-Related-Eating (SRE) is caused by biochemical reactions in the body that trigger False-Food-Cravings.

A perfect example of this reaction is PMS, which is generally accompanied by cravings for chocolate, sweets, crunchy foods, and sweet-salty foods (such as chocolate-covered potato chips).

Stress-Related-Eating (SRE) leads to weight gain because the foods carved during SRE elevate glucose production and adipose tissue fat storage. Glucose-elevating foods are High Glycemic. They help sooth stress, but also stimulate fat-storage.

BORESHA B-SKINNY™ COFFEE
DESIGNED BY LEADING GLYCEMIC INDEX RESEARCHERS

Why is it important to have glycemic researchers design an energy drink?

Because energy drinks cause FAT-STORAGE in humans. What is the point of energizing the body and stimulating fat-storage at the same time?

The only way to engineer an energy drink that does not stimulate fat-storage is to incorporate the Glycemic Index and the Cephalic Response into the equation and to use Buffered Caffeine instead of regular caffeine.

COPY-CAT PRODUCTS

Boresha B-Skinny™ Coffee cannot be copied due to the non-reverse-engineerable formula, proprietary manufacturing process, and strong Patent status.

The information and science found herein is Copyright, Trademark, and Patent protected by the United States Federal government.

CONTRAINDICATIONS

Taking Boresha B-Skinny™ Coffee too close to bedtime may result in difficulty falling asleep, due to the energy-enhancing effects.